?Humans and fruitflies those pesky little buggers that are irresistibly attracted to overripe fruit share more than a sweet tooth. Both rely on the same insulin regulated molecular pathway to maintain their energy balance when starved for food, reports a team of researchers at the Salk Institute for Biological Studies. Their findings, published in the May 7, 2008 issue of Cell Metabolism,
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"Basic biological processes are remarkably well conserved through evolution,
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But it’s not simply a case of "more of the same." "You may wonder why do these experiments in flies"" asks Thomas,
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Small and easy to breed,
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After a meal, the cells release insulin into the circulatory system, which signals the "fat body," the flies’ energy storing organ,
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In earlier mouse studies, Montminy discovered a metabolic switch, a protein called TORC2,
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To understand TORCs role in fly metabolism, a team of researchers who split their team between Montminy’s and Thomas’ lab,
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Without functional TORC,
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After it had become clear that fasting put TORC to work in the nucleus,
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"Beyond its role in glucose and fat metabolism,
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Buy Authentic Georgetown 11s Low Cheap Sale," explains Montminy." Based on insulin’s ability to shut down the TORC switch during feeding,
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Source: Salk Institute
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